Lysostaphin is a natural enzyme that functions as an antibacterial against staphylococcal infections including Staphylococcal aureus and Staphylococcal epidermidis. It is effective against combating these infections because it attacks the bacterial cellular wall of staphylococci, and is capable of destroying the bacterium within minutes. Staphylococcal aureus infections, particularly MRSA (methicillin-resistant Staphylococcal aureus), are a continuing concern within healthcare settings. This is because they are responsible for a large portion of infections which arise from implantable devices such as catheters, which act to provide a pathway for MRSA to travel into the body. While anyone may contract a staphylococcal infection, they are of particular concern within certain groups such as those residing in nursing homes. The elderly population is generally at higher risk due to their vulnerable state and weakened immune systems. Contraction of such infections not only lead to skin infections, but when the bacteria enters the bloodstream, it may spread into other organs, infecting them, and may also lead to sepsis, pneumonia, and other severe complications including death.
MRSA bacterial cells are capable of forming a community of bacterial cells, known as biofilms, on medical devices and damaged tissue, thereby surviving and spreading infection. Unfortunately, the biofilms that form on such devices are generally antibiotic resistant, and it becomes increasingly difficult to treat the infection. As a result, the device will either have to be removed or replaced via surgery, and the patient will require an intensive antibiotic treatment plan. However, subjecting the patient to this type of invasive procedure heightens their risk for further complications. Additionally, despite this course of action, infection reoccurrence is still relatively high due to the increasing antibiotic-resistant nature of the bacterium. Therefore, lysostaphin has been studied and considered as an alternative anti-staphylococcal treatment. This is because lysostaphin has been known to effectively destroy staphylococcal bacterial cells, and has been demonstrated to be particularly effective against MRSA.



